Brands, Medical Use, Clinical Data
- Anti-infective Agents
- Antineutropenic Agents
- Immunomodulatory Agents
Brands / Synonyms
G-CSF; Granulocyte colony-stimulating factor precursor; Lenograstim; Neupogen; Neupogen (Amgen Inc.)
Recombinant human G-CSF (Granulocyte colony stimulating factor), 175 residues, expressed in E. coli. The protein has an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal methionine necessary for expression in E coli.
Increases leukocyte production, for treatment in non-myeloid cancer,neutropenia and bone marrow transplant
Used in the treatment of chemotherapy-induced neutropenia by enhancing the production of neutrophils. Filgrastim acts on hematopoietic cells by binding to specific cell surface receptors thereby stimulating proliferation, differentiation, commitment, and end cell functional activation.
Mechanism of Action
Filgrastim binds to the G-CSF receptor. As a G-CSF analog, it controls proliferation of committed progenitor cells and influences their maturation into mature neutrophils. Filgrastim also stimulates the release of neutrophils from bone marrow storage pools and reduces their maturation time. Filgrastim acts to increase the phagocytic activity of mature neutrophils. In patients receiving cytotoxic chemotherapy, Filgrastim can accelerate neutrophil recovery, leading to a reduction in duration of the neutropenic phase
Biotrnasformation / Drug Metabolism