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Active ingredient: Fenofibrate - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C20H21ClO4

Chemical Name

1-methylethyl2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoate

Chemical Structure

Molecular Weight

360.831 g/mol

Physical State

Solid

Melting Point

80.5 °C

Water Solubility

0.25mg/ml at 25 °C

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NamePPAR-alpha
Gene NamePPARA
SynonymsPeroxisome proliferator activated receptor alpha; PPAR-alpha
Specific FunctionReceptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids

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