Chemisty and Biological Activity
Chemical Formula
C8H15N7O2S3
Chemical Name
2-[4-[2-(amino-sulfamoylimino-methyl)ethylsulfanylmethyl]-1,3-thiazol-2- yl]guanidine
Chemical Structure
Molecular Weight
337.449 g/mol
Physical State
Solid
Melting Point
163-164 oC
Water Solubility
1.1 mg/mL
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
Not Available
Primary Drug Target
| Name | Histamine H2 Receptor | | Gene Name | HRH2 | | Synonyms | Histamine H2 receptor; H2R; Gastric receptor I | | Specific Function | The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway |
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