Brands, Medical Use, Clinical Data
Drug Category
- Coagulants
- Thrombotic Agents
Dosage Forms
- Liquid
- Powder for Solution
Brands / Synonyms
Benefix (Genetics Institute)
; Christmas factor; Coagulation factor IX precursor; Plasma thromboplastin component; PTC
Description
Human Factor IX protein, produced by recombinant DNA technology for use in therapy of factor IX deficiency, known as hemophilia B or Christmas disease. Coagulation Factor IX (Recombinant) is a glycoprotein with an approximate molecular mass of 55,000 Da consisting of 415 amino acids in a single chain. It has a primary amino acid sequence that is identical to the Ala 148 allelic form of plasma-derived factor IX.
Indications
For treatment of hemophilia (Christmas diseae)
Pharmacology
Binds vitamin K and factor VIIIa. Cleaves the Arg-Ile bond in factor X to form active factor Xa. Plays a key role in blood coagulation and clotting. Injections of factor IX are used to treat hemophilia B, which is sometimes called Christmas disease. AlphaNine is injected to increase plasma levels of Factor IX and can temporarily correct this coagulation defect.
Mechanism of Action
Cleaves the Arg-Ile bond in Factor X to form active factor Xa leading to coagulation and clotting.
Absorption
Not Available
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
Not Available
Drug Interactions
Not Available
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