Chemisty and Biological Activity
Chemical Formula
C17H21NO3
Chemical Name
1,8-diethyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acid
Chemical Structure
Molecular Weight
287.354 g/mol
Physical State
Solid
Melting Point
145-148 oC
Water Solubility
16 mg/L
Isoelectric Point
4.65
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
CYP2C9
Primary Drug Target
Name | COX-1 | Gene Name | PTGS1 | Synonyms | Prostaglandin G/H synthase 1 precursor; EC 1.14.99.1; Cyclooxygenase-1; COX-1; Prostaglandin-endoperoxide synthase 1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1 | Specific Function | May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells | Pathway | map00590 Prostaglandin and leukotriene metabolism | Reaction | arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O |
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