Brands, Medical Use, Clinical Data
- Antirheumatic Agents
- Immunomodulatory Agents
- powder for solution
Brands / Synonyms
CD120b; Enbrel; Enbrel (Immunex Corp)
; Etanercept[Contains: Tumor necrosis factor binding protein 2,TBPII,TBP-2]; p75; p80 TNF-alpha receptor; TNF-R2; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor superfamily member 1B precursor; Tumor necrosis factor receptor type II
Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. It consists of 934 amino acids
For treatment of severe adult and juvenille rheumatoid arthritis
Used in the treatment of rheumatoid arthritis and the reduction of the adverse effects of tumor necrosis factor (TNF). TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Elevated levels of TNF are found in tissues and fluids of patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis (AS), and plaque psoriasis. Etanercept binds specifically to tumor necrosis factor (TNF) and blocks its interaction with cell surface TNF receptors.
Mechanism of Action
There are two distinct receptors for TNF (TNFRs), a 55 kilodalton protein (p55) and a 75 kilodalton protein (p75). The biological activity of TNF is dependent upon binding to either cell surface receptor (p75 or p55). Etanercept is a dimeric soluble form of the p75 TNF receptor that can bind to two TNF molecules, thereby effectively removing them from circulation.
Biotrnasformation / Drug Metabolism