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Active ingredient: Estrone - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Antineoplastic Agents
  • Osteoporosis Prophylactic
  • Anti-menopausal Agents
  • Estrogens

Dosage Forms

  • Vaginal cream
  • Vaginal suppository
  • Patch
  • Skin gel
  • Tablet
  • IM injectable suspension

Brands / Synonyms

Aquacrine; Crinovaryl; Cristallovar; Crystogen; Destrone; Disynformon; Eemt H.s.; Endofolliculina; Esterone; Estrin; Estrogenic Substance; Estrol; Estron; Estrona; Estrona [Inn-Spanish]; Estrona [Spanish]; Estrone [Usan:Inn]; Estrone-A; Estronum [Inn-Latin]; Estrovarin; Estrugenone; Estrusol; Femestrone Inj.; Femestrone Injection; Femidyn; Fermidyn; Folikrin; Folipex; Folisan; Follestrine; Follestrol; Follicular Hormone; Folliculin; Folliculine; Folliculine Benzoate; Follicunodis; Follidrin; Glandubolin; GSS 33; Hiestrone; Hormestrin; Hormofollin; Hormovarine; Kestrone; Ketodestrin; Ketohydroxy-Estratriene; Ketohydroxyestrin; Ketohydroxyoestrin; Ketophydroxyestrin; Kolpon; Menagen; Menformon; Menformon A; Mestronaq; Oestrin; Oestroform; Oestrone; Oestrone [Steroidal Oestrogens]; Oestronum; Oestroperos; OVEX; Ovifollin; Penncap M; Perlatan; Sinafid M-48; Solliculin; Theelin; Thelestrin; Thelykinin; Thynestron; Tokokin; Unden; Wynestron; Wynestronpencap M


For management of Menopausal and postmenopausal disorders


Estrone, a synthetically prepared or naturally occurring steroidal estrogen obtained from pregnant equine urine, is the primary circulating estrogen after menopause. Estrone is naturally derived from the peripheral conversion of androstenedione by an aromatase enzyme found in adipose tissues and is converted to estradiol in peripheral tissues. Estropipate is piperazine-stabilized estrone sulfate. Estrone, and estropipate are used to treat abnormalities related to gonadotropin hormone dysfunction, vasomotor symptoms, atrophic vaginitis, and vulvar atrophy associated with menopause, and for the prevention of osteoporosis due to estrogen deficiency.

Mechanism of Action

Estrogens enter the cells of responsive tissues (e.g., female organs, breasts, hypothalamus, pituitary) where they interact with a protein receptor, estrogen receptors, subsequently increasing the rate of synthesis of DNA, RNA, and some proteins. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.




Symptoms of overdose include nausea and vomiting. Withdrawal bleeding may occur in females.

Biotrnasformation / Drug Metabolism



Estrogens/ estradiol/ estrones should not be used:

During Pregnancy: Vaginal Cream, Oral Tablets, Transdermal. If you think you may be pregnant, do not use any form of estrogen-containing drug. Using estrogens while you are pregnant may cause your unborn child to have birth defects. Estrogens do not prevent miscarriage.
If You Have Unusual Vaginal Bleeding Which Has not Been Evaluated by Your Doctor: Vaginal Cream, Oral Tablets, Transdermal. Unusual vaginal bleeding can be a warning sign of cancer of the uterus, especially if it happens after menopause. Your doctor must find out the cause of the bleeding so that he or she can recommend the proper treatment. Taking estrogens without visiting your doctor can cause you serious harm if your vaginal bleeding is caused by cancer of the uterus.
If You Have Had Cancer: Since estrogens increase the risk of certain types of cancer, you should not use estrogens if you have ever had cancer of the breast or uterus, unless your doctor recommends that the drug may help in cancer treatment. (For certain patients with breast or prostate cancer, estrogens may help.)
If You Have any Circulation Problems: Estrogen drugs should not be used except in unusually special situations in which your doctor judges that you need estrogen therapy so much that the risks are acceptable. Men and women with abnormal blood clotting conditions should avoid estrogen use (see Dangers of Estrogens).
When They do not Work: During menopause, some women develop nervous symptoms or depression. Estrogens do not relieve these symptoms. You may have heard that taking estrogens for years after menopause will keep your skin soft and supple and keep you feeling young. There is no evidence for these claims and such long-term estrogen use may have serious risks.
After Childbirth or When Breastfeeding a Baby: Estrogens should not be used to try to stop the breasts from filling with milk after a baby is born. Such treatment may increase the risk of developing blood clots (see Dangers of Estrogens).
If you are breastfeeding, you should avoid using any drugs because many drugs pass through to the baby in the milk. While nursing a baby, you should take drugs only on the advice of your health care provider.

Drug Interactions

Drug Interactions

This medicine may be affected by the drug cholestyramine and should not be taken with any form of estrogen therapy. Talk to your pharmacist for more information.
Drugs that may decrease the effects of this medicine include:
phenytoin (Dilantin)
carbamazepine (Tegretol)
Estrogens may decrease the effects of benzodiazepines (lorezepam
temezepam). If you are taking these medicines together or you have further questions about drug interactions
talk to your doctor or pharmacist.
Consult your doctor or pharmacist if you are taking any of the following:
seizure medications
medications to help you sleep

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