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Active ingredient: Ertapenem - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name

3-[5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl-7-(1- hydroxyethyl)-2-methyl-6-oxo-5-azabicyclo[3.2.0]hept-3-ene-4- carboxylic acid

Chemical Structure

Molecular Weight

475.516 g/mol

Physical State


Melting Point

Not Available

Water Solubility

Soluble as sodium salt

Isoelectric Point

Not Available

Organisms Affected

Enteric bacteria and other eubacteria

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NamePenicillin-binding protein 1B
Gene NamemrcB
SynonymsPBP-1b; PBP1b; Murein polymerase[Includes: Penicillin-insensitive transglycosylase; EC; Peptidoglycan glycosyltransferase; Peptidoglycan TGase; Penicillin- sensitive transpeptidase; EC 3.4.-.-; DD-transpeptidase]
General FunctionCell wall/membrane/envelope biogenesis
Specific FunctionCell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
Pathwaymap00550 Peptidoglycan biosynthesis
Reaction[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n- $diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu- $L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1->4)- $Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1- $diphosphoundecaprenol + undecaprenyl diphosphate

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