Chemisty and Biological Activity
Chemical Formula
C815H1317N233O241S5
Chemical Name
Human erythropoietin
Chemical Structure
APPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYA
WKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVS
GLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLR
GKLKLYTGEACRTGDR
Molecular Weight
18396.1
Physical State
Liquid
Melting Point
53 oC (Arakawa, T. et al., Biosci. Biotechnol. Biochem. 65:1321-1327 (2001)).
Water Solubility
Not Available
Isoelectric Point
8.75
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
Not Available
Primary Drug Target
Name | Erythropoietin receptor | Gene Name | EPOR | Synonyms | Erythropoietin receptor precursor; EPO-R | Specific Function | Isoform EPOR-T, missing the cytoplasmic tail, acts as a dominant-negative receptor of EPOR-mediated signaling |
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