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Active ingredient: Epoetin Alfa - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C815H1317N233O241S5

Chemical Name

Human erythropoietin

Chemical Structure

APPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYA WKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVS GLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLR GKLKLYTGEACRTGDR

Molecular Weight

18396.1

Physical State

Liquid

Melting Point

53 oC (Arakawa, T. et al., Biosci. Biotechnol. Biochem. 65:1321-1327 (2001)).

Water Solubility

Not Available

Isoelectric Point

8.75

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameErythropoietin receptor
Gene NameEPOR
SynonymsErythropoietin receptor precursor; EPO-R
Specific FunctionIsoform EPOR-T, missing the cytoplasmic tail, acts as a dominant-negative receptor of EPOR-mediated signaling

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