Active ingredient: Eplerenone - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C24H30O6

Chemical Name

Not Available

Chemical Structure

Molecular Weight

414.491 g/mol

Physical State

Solid

Melting Point

Not Available

Water Solubility

Slightly soluble

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP3A4

Primary Drug Target

Name	Mineralocorticoid Receptor
Gene Name	NR3C2
Synonyms	Mineralocorticoid receptor; MR
General Function	Carbohydrate transport and metabolism
Specific Function	Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels