Brands, Medical Use, Clinical Data
- Immunomodulatory Agents
- Solution (Subcutaneous Injection)
Brands / Synonyms
anti alphaL integrin; antiCD11 alpha; hu1124; Raptiva; Raptiva (Genentech Inc)
Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin.
For treatment of psoriasis
Lymphocyte activation and trafficking to skin play a role in the pathophysiology of chronic plaque psoriasis. In psoriatic skin, ICAM-1 cell surface expression is upregulated on endothelium and keratinocytes. Raptiva inhibits the binding of LFA-1 to the intercellular adhesion molecule-1 (ICAM-1), thereby inhibiting the adhesion of leukocytes to other cell types.
Mechanism of Action
Raptiva binds to CD11a, a subunit of leukocyte function antigen-1 (LFA-1), which is expressed on all leukocytes. As a result Raptiva decreases cell surface expression of CD11a.
Biotrnasformation / Drug Metabolism