DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Active ingredient: Econazole - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C18H15Cl3N2O

Chemical Name

1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)-ethyl]imidazole

Chemical Structure

Molecular Weight

381.683 g/mol

Physical State

Not Available

Melting Point

Not Available

Water Solubility

Not Available

Isoelectric Point

Not Available

Organisms Affected

Yeast and other fungi

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
Name14-alpha demethylase (Yeast)
Gene NameERG11
SynonymsCytochrome P450 51; EC 1.14.13.70; CYPLI; P450-LIA1; Sterol 14- alpha demethylase; Lanosterol 14-alpha demethylase; P450-14DM
General FunctionSecondary metabolites biosynthesis, transport and catabolism
Specific FunctionCatalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol
Reactionobtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 3 NADP+ + 3 H2O

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017