Chemisty and Biological Activity
Chemical Formula
C18H15Cl3N2O
Chemical Name
1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)-ethyl]imidazole
Chemical Structure
Molecular Weight
381.683 g/mol
Physical State
Not Available
Melting Point
Not Available
Water Solubility
Not Available
Isoelectric Point
Not Available
Organisms Affected
Yeast and other fungi
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
Not Available
Primary Drug Target
Name | 14-alpha demethylase (Yeast) | Gene Name | ERG11 | Synonyms | Cytochrome P450 51; EC 1.14.13.70; CYPLI; P450-LIA1; Sterol 14- alpha demethylase; Lanosterol 14-alpha demethylase; P450-14DM | General Function | Secondary metabolites biosynthesis, transport and catabolism | Specific Function | Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol | Reaction | obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 3 NADP+ + 3 H2O |
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