Brands, Medical Use, Clinical Data
Drug Category
- Pregnadien derivatives
- Progesterones
Dosage Forms
- Tablets for oral administration (10mg)
Brands / Synonyms
10alpha-Isopregnenone; Didrogesterone [DCIT]; Diphaston; Dufaston; Duphaston; Duvaron; Dydrogesterona [INN-Spanish]; Dydrogesterone [USAN:BAN:INN:JAN]; Dydrogesteronum [INN-Latin]; Gestatron; Gynorest; Hydrogesterone; Hydrogestrone; Isopregnenone; Prodel; Retrone; Terolut
Indications
Used to treat irregular duration of cycles and irregular occurrence and duration of periods caused by progesterone deficiency. Also used to prevent natural abortion in patients who have a history of habitual abortions.
Pharmacology
Dydrogesterone is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. At therapeutic levels, dydrogesterone has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore, dydrogesterone is non-androgenic, non-estrogenic, non-corticoid, non-anabolic and is not excreted as pregnanediol. Dydrogesterone helps to regulate the healthy growth and normal shedding of the uterus lining. Therefore, it may be useful in the treatment of menstrual disorders such as absent, irregular or painful menstrual periods, infertility, premenstrual syndrome and endometriosis.
Mechanism of Action
Dydrogesterone is a progestogen that works by regulating the healthy growth and normal shedding of the womb lining by acting on progesterone receptors in the uterus.
Absorption
Rapidly absorbed in the gastrointestinal tract.
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
Contraindicated in patients with undiagnosed vaginal bleeding nor to those with a history of thromboembolic disorders.
Drug Interactions
Not Available
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