Brands, Medical Use, Clinical Data
Drug Category
Dosage Forms
Brands / Synonyms
Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV; Vitamin K-dependent protein C precursor; Xigris; Xigris (Eli Lilly & Co)
Description
Human Protein C that has been enzymatically activated by cleavage with thrombin and subsequently purified. Drotrecogin alfa (activated) is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond.
Indications
For treatment of severe sepsis
Pharmacology
Activated Protein C exerts an antithrombotic effect by inhibiting (cleaving) Factors Va and VIIIa. In vitro data indicate that Activated Protein C has indirect profibrinolytic activity through its ability to inhibit plasminogen activator inhibitor-1 (PAI-1) and limiting generation of activated thrombin-activatable-fibrinolysis-inhibitor. The net effect is the reduction or elimination of blood clots
Mechanism of Action
Activated protein C combines with protein S on platelet surfaces and then degrades factor Va and factor VIIIa.
Absorption
Not Available
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
Not Available
Drug Interactions
Not Available
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