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Active ingredient: Drotrecogin Alfa - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Antisepsis Agents

Dosage Forms

  • Powder for solution

Brands / Synonyms

Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV; Vitamin K-dependent protein C precursor; Xigris; Xigris (Eli Lilly & Co)


Human Protein C that has been enzymatically activated by cleavage with thrombin and subsequently purified. Drotrecogin alfa (activated) is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond.


For treatment of severe sepsis


Activated Protein C exerts an antithrombotic effect by inhibiting (cleaving) Factors Va and VIIIa. In vitro data indicate that Activated Protein C has indirect profibrinolytic activity through its ability to inhibit plasminogen activator inhibitor-1 (PAI-1) and limiting generation of activated thrombin-activatable-fibrinolysis-inhibitor. The net effect is the reduction or elimination of blood clots

Mechanism of Action

Activated protein C combines with protein S on platelet surfaces and then degrades factor Va and factor VIIIa.


Not Available


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Biotrnasformation / Drug Metabolism

Not Available


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Drug Interactions

Not Available

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