Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
Not Available
Primary Drug Target
Name
Apoptosis regulator Bcl-2
Gene Name
BCL2
Specific Function
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)