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Active ingredient: Docetaxel - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C43H53NO14

Chemical Name

Not Available

Chemical Structure

Molecular Weight

807.879 g/mol

Physical State

Solid

Melting Point

232 oC

Water Solubility

Practically insoluble (0.025 mg/L)

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameApoptosis regulator Bcl-2
Gene NameBCL2
Specific FunctionSuppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)

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