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Active ingredient: Diethylstilbestrol - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Antineoplastic Agents, Hormonal
  • Carcinogens
  • Estrogens, Non-Steroidal

Dosage Forms

  • Solution for injection (250 mg/5 mL)
  • Tablet (0.1 mg, 0.5 mg and 1 mg)

Brands / Synonyms

Acnestrol; Agostilben; Antigestil; Bio-des; Bufon; Climaterine; Comestrol; Comestrol estrobene; Cyren; Cyren A; Dawe's destrol; DEB; DES; Desma; Destrol; Di-Estryl; Diastyl; Dibestrol; DiBestrol 2 Premix; Dicorvin; Diethylstilbesterol; Diethylstilbestrol BP; Diethylstilboesterol; Dietilestilbestrol; Distilbene; Domestrol; Dyestrol; Estilben; Estilbin MCO; Estril; Estrobene; Estrogen; Estrogenine; Estromenin; Estrosyn; Follidiene; Fonatol; Grafestrol; Gynopharm; Hi-Bestrol; Idroestril; Iscovesco; Makarol; Menostilbeen; Micrest; Microest; Milestrol; neo-Oestranol 1; Neo-Oestranol I; New-Estranol 1; OeKolp; Oestrogenine; Oestrol vetag; Oestromenin; Oestromensil; Oestromensyl; Oestromienin; Oestromon; Pabestrol; Palestrol; Percutatrine oestrogenique iscovesco; Protectona; Rcra waste number U089; Rumestrol 1; Rumestrol 2; Sedestran; Serral; Sexocretin; Sibol; Sintestrol; Stibilium; Stil; Stil-Rol; Stilbestroform; Stilbestrol; Stilbestrone; Stilbetin; Stilboefral; Stilboestroform; Stilboestrol; Stilbofolin; Stilbofollin; Stilbol; Stilkap; Stilphostrol; strobene; Synestrin; Synthestrin; Synthoestrin; Synthofolin; Syntofolin; Tampovagan stilboestrol; trans-Diethylstilbesterol; trans-Diethylstilbestrol; trans-Diethylstilboesterol ; Tylosterone; Vagestrol


Used in the treatment of prostate cancer. Previously used in the prevention of miscarriage or premature delivery in pregnant women prone to miscarriage or premature delivery.


Diethylstilbestrol is a synthetic estrogen that was developed to supplement a woman's natural estrogen production. In 1971, the Food and Drug Administration (FDA) issued a Drug Bulletin advising physicians to stop prescribing DES to pregnant women because it was linked to a rare vaginal cancer in female offspring.

Mechanism of Action

Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).


Not Available


Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females.

Biotrnasformation / Drug Metabolism



Not Available

Drug Interactions

May interact anticoagulants (altered hypo-prothrombinemic effect), barbiturates, rifampin and other inducers of hepatic microsomal enzyme oxidation system (decreased effect of diethylstilbestrol), corticosteroids (increased effect of corticosteroids).

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