Brands, Medical Use, Clinical Data
- Anticholinergic Agents
Brands / Synonyms
Atumin; Bentomine; Bentyl; Bentyl Hydrochloride; Bentylol; Bentylol Hydrochloride; Di-Syntramine; Dicicloverina [Inn-Spanish]; Dicyclomine; Dicyclomine Hcl; Dicyclomine Hydrochloride; Dicycloverin; Dicycloverin Hydrochloride; Dicycloverine; Dicycloverine Hydrochloride; Dicycloverinum [Inn-Latin]; Diethylaminocarbethoxybicyclohexyl Hydrochloride; Diocyl; Diocyl Hydrochloride; Dyspas; Formulex; Kolantyl Hydrochloride; Mamiesan; Merbentyl; Oxityl-P; Procyclomin; Sawamin; Spasmoban; Wyovin; Wyovin Hydrochloride
For the treatment of functional bowel/irritable bowel syndrome
including Colicky abdominal pain; diverticulitis
Dicyclomine is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Dicyclomine is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Dicyclomine inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions.
Mechanism of Action
Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic).
Biotrnasformation / Drug Metabolism
- 1. Obstructive uropathy
- 2. Obstructive disease of the gastrointestinal tract
- 3. Severe ulcerative colitis
- 4. Reflux esophagitis
- 5. Unstable cardiovascular status in acute hemorrhage
- 6. Glaucoma
- 7. Myasthenia gravis
- 8. Evidence of prior hypersensitivity to dicyclomine hydrochloride or other ingredients of these
- 9. Infants less than 6 months of age
- 10. Nursing Mothers
The following agents may increase certain actions or side effects of anticholinergic drugs. amantadine
antiarrhythmic agents of class (e.g. quinidine), antihistamines antipsychotic agents (e.g. phenothiazines),
benzodiazepines. MAO inhibitors, narcotic analgesics (e.g., meperidine), nitrates and nitrites, sympathomimetic
agents, tricyclic antidepressants, and other drugs having anticholinergic activity.
Anticholinergics antagonize the effects of antiglaucoma agents. Anticholinergic drugs in the presence of increased
intraocular pressure may be hazardous when taken concurrently with agents such as corti costeroids..
Anticholinergic agents may affect gastrointestinal absorption of various drugs, such as slowly dissolving dosage
forms of digoxin; increased serum digoxin concentrations may result.
Anticholinergic drugs may antagonize the effects of the drugs that alter gastrointestinal motility, such as
metoclopramide. Because antacids may interfere with the absorption of anticholinergic agents, simultaneous use of
these drugs should be avoided.
The inhibiting effects of anticholinergic drugs on gastric hydrochloric acid secretion are antagonized by agents
used to treat achlorhydria and those used to test gastric secretion.