Brands, Medical Use, Clinical Data
Drug Category
- Diuretics
- Anti-Addison Agents
Dosage Forms
- Cream
- Suspension
- Implantation
- Pellet
Brands / Synonyms
Cortexone M; Deoxycorticosterone Pivalate; Deoxycorticosterone Trimethylacetate; Deoxycortolone Pivalate; Deoxycortone Pivalate; Deoxycortone Trimethylacetate; Desoxycorticosterone Trimethylacetate; Desoxycortone Pivalate; DOCP; DTMA; Neodin-Depositum; Percorten; Percorten M; Percorten Pivalate
Indications
For treatment of adrenocortical insufficiency especially in multiple sclerosis, congenital cerebral palsy, polyarteritis nodosa, and rheumatoid arthritis.
Pharmacology
Used to treat adrenocortical insufficiency, desoxycorticosterone pivalate is a mineralocorticoid hormone and an analogue of desoxycorticosterone. It primarily acts on the metabolism of sodium, potassium and water. When the drug is given, there is decreased excretion of sodium accompanied by increased excretion of potassium; the concentration of sodium in the blood is thereby increased whereas that of potassium is decreased. There is a concomitant increase in the volume of blood and extracellular fluids, with a fall in hematocrit. It increases the rate of renal tubular absorption of sodium.
Mechanism of Action
Desoxycorticosterone Pivalate binds to the mineralocorticoid receptor. Mineralocorticoids are a family of steroids, secreted by the adrenal cortex, necessary for the regulation of a number of metabolic processes including electrolyte regulation. Desoxycorticosterone pivalate exerts its effect through its interaction with the mineralocorticoid receptor (MR), whereby it reacts with the receptor proteins to form a steroid-receptor complex. This complex moves into the nucleus, where it binds to chromatin which results in genetic transcription of cellular DNA to messenger RNA. The steroid hormones appear to induce transcription and synthesis of specific proteins, which produce the physiological effects seen after administration.
Absorption
Not Available
Toxicity
Symptoms of overdose include polyuria, polydipsia, increased blood volume, edema, and cardiac enlargement.
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
Desoxycorticosterone Pivalate is contraindicated in
patients with systemic fungal infections and in those with a history of possible or known hypersensitivity to this
agent.
Drug Interactions
Not Available
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