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Active ingredient: Dapsone - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C12H12N2O2S

Chemical Name

4-(4-aminophenyl)sulfonylaniline

Chemical Structure

Molecular Weight

248.302 g/mol

Physical State

Solid

Melting Point

175.5 oC

Water Solubility

380 mg/L

Isoelectric Point

2.41

Organisms Affected

Mycobacteria

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP2C9

Primary Drug Target
NameDihydropteroate synthase (Pneumocystis carinii)
Gene NameFAS
SynonymsFolic acid synthesis protein [Includes: Dihydroneopterin aldolase; EC 4.1.2.25; DHNA; FASA; FASB; Dihydropteroate synthase; EC 2.5.1.15; DHPS; Dihydropteroate pyrophosphorylase; FASC; 2- amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; EC 2.7.6.3; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; FASC]
General FunctionCoenzyme transport and metabolism
Pathwaymap00790 Folate biosynthesis
Reaction2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8- dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde

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