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Active ingredient: Dapsone - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name


Chemical Structure

Molecular Weight

248.302 g/mol

Physical State


Melting Point

175.5 oC

Water Solubility

380 mg/L

Isoelectric Point


Organisms Affected


Phase 1 Metabolising Enzyme (1-st Step of Metabolism)


Primary Drug Target
NameDihydropteroate synthase (Pneumocystis carinii)
Gene NameFAS
SynonymsFolic acid synthesis protein [Includes: Dihydroneopterin aldolase; EC; DHNA; FASA; FASB; Dihydropteroate synthase; EC; DHPS; Dihydropteroate pyrophosphorylase; FASC; 2- amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; EC; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; FASC]
General FunctionCoenzyme transport and metabolism
Pathwaymap00790 Folate biosynthesis
Reaction2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8- dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde

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