Chemisty and Biological Activity
Chemical Formula
C12H12N2O2S
Chemical Name
4-(4-aminophenyl)sulfonylaniline
Chemical Structure
Molecular Weight
248.302 g/mol
Physical State
Solid
Melting Point
175.5 oC
Water Solubility
380 mg/L
Isoelectric Point
2.41
Organisms Affected
Mycobacteria
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
CYP2C9
Primary Drug Target
Name | Dihydropteroate synthase (Pneumocystis carinii) | Gene Name | FAS | Synonyms | Folic acid synthesis protein [Includes: Dihydroneopterin aldolase; EC 4.1.2.25; DHNA; FASA; FASB; Dihydropteroate synthase; EC 2.5.1.15; DHPS; Dihydropteroate pyrophosphorylase; FASC; 2- amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; EC 2.7.6.3; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; FASC] | General Function | Coenzyme transport and metabolism | Pathway | map00790 Folate biosynthesis | Reaction | 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8- dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde |
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