Active ingredient: Dantrolene - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C14H10N4O5

Chemical Name

1-[[5-(4-nitrophenyl)-2-furyl]methylideneamino]imidazolidine-2,4-dione

Chemical Structure

Molecular Weight

314.253 g/mol

Physical State

Solid

Melting Point

279-280 oC

Water Solubility

Low (146 mg/L)

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target

Name	Ryanodine receptor 1
Gene Name	RYR1
Synonyms	Skeletal muscle-type ryanodine receptor; RyR1; RYR-1; Skeletal muscle calcium release channel
General Function	Translation, ribosomal structure and biogenesis
Specific Function	Communication between transverse-tubules and sarcoplasmic reticulum. Contraction of skeletal muscle is triggered by release of calcium ions from SR following depolarization of T-tubules