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Active ingredient: Dantrolene - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name


Chemical Structure

Molecular Weight

314.253 g/mol

Physical State


Melting Point

279-280 oC

Water Solubility

Low (146 mg/L)

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameRyanodine receptor 1
Gene NameRYR1
SynonymsSkeletal muscle-type ryanodine receptor; RyR1; RYR-1; Skeletal muscle calcium release channel
General FunctionTranslation, ribosomal structure and biogenesis
Specific FunctionCommunication between transverse-tubules and sarcoplasmic reticulum. Contraction of skeletal muscle is triggered by release of calcium ions from SR following depolarization of T-tubules

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