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Active ingredient: Cytarabine - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name

4-amino-1-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2- yl]pyrimidin-2-one

Chemical Structure

Molecular Weight

243.217 g/mol

Physical State


Melting Point


Water Solubility

Freely soluble

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Cytidine deaminase

Primary Drug Target
NameDNA Polymerase (human)
Gene NamePOLB
SynonymsDNA polymerase beta; EC; EC 4.2.99.-
General FunctionReplication, recombination and repair
Specific FunctionRepair polymerase. Conducts "gap-filling" DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Has a 5'-deoxyribose-5- phosphate lyase (dRP lyase) activity
Pathwaymap00230 Purine metabolism map00240 Pyrimidine metabolism map03030 DNA polymerase
Reactiondeoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

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