Chemisty and Biological Activity
Chemical Formula
C9H13N3O5
Chemical Name
4-amino-1-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2- yl]pyrimidin-2-one
Chemical Structure
Molecular Weight
243.217 g/mol
Physical State
Solid
Melting Point
212-213oC
Water Solubility
Freely soluble
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
Cytidine deaminase
Primary Drug Target
Name | DNA Polymerase (human) | Gene Name | POLB | Synonyms | DNA polymerase beta; EC 2.7.7.7; EC 4.2.99.- | General Function | Replication, recombination and repair | Specific Function | Repair polymerase. Conducts "gap-filling" DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Has a 5'-deoxyribose-5- phosphate lyase (dRP lyase) activity | Pathway | map00230 Purine metabolism
map00240 Pyrimidine metabolism
map03030 DNA polymerase | Reaction | deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) |
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