Brands, Medical Use, Clinical Data
- Immunmodulatory Agents
- Capsule (liquid-filled)
- Capsule (liquid-filled for emulsion)
- Solution (oral)
- Solution (IV infusion)
Brands / Synonyms
Gengraf; Gengraf (Abbott labs); Neoral; Neoral (Novartis); Restasis; Restasis (Allergan Inc); Sandimmune; Sandimmune (Novartis)
11 amino acid cyclic peptide. It is produced as a metabolite by the fungus species Beauveria nlyea.
For treatment of transplant rejection, rheumatoid arthritis, severe psoriasis
Used in immunosuppression for prophylactic treatment of organ transplants, cyclosporine exerts specific and reversible inhibition of immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited. The T1-helper cell is the main target, although the T1-suppressor cell may also be suppressed. Sandimmune (cyclosporine) also inhibits lymphokine production and release including interleukin-2.
Mechanism of Action
Cyclosporine binds to cyclophillin. The complex then inhibits calcineurin which is normally responsible for activating transcription of interleukin 2. Cyclosporine also inhibits lymphokine production and ineterluekin relase.
Biotrnasformation / Drug Metabolism