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Active ingredient: Cromolyn - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Anti-Asthmatic Agents

Dosage Forms

  • Capsule
  • Liquid
  • Metered-dose (aerosol)
  • Ointment
  • Powder
  • Solution
  • Spray

Brands / Synonyms

Aarane; Acide Cromoglicique [Inn-French]; Acido Cromoglicico [Inn-Spanish]; Acidum Cromoglicicum [Inn-Latin]; Alercom; Alerion; Allergocrom; Apo-Cromolyn; Children's Nasalcrom; Colimune; Crolom; Cromoglicic Acid; Cromoglycic Acid; Cromolyn; Cromolyn Nasal Solution; Cromolyn Sodium; Cromoptic; Cromovet; Diethyl Cromoglycicate; Fivent; Gastrocrom; Gastrofrenal; Gen-Cromoglycate; Inostral; Intal; Intal Inhaler; Intal Syncroner; Introl; Irtan; Lomudal; Lomupren; Lomusol; Lomuspray; Nalcrom; Nalcron; Nasalcrom; Nasmil; Novo-Cromolyn; Opticrom; Opticron; Pms-Sodium Cromoglycate; Rynacrom; Sodium Cromoglycate; Sofro; Vistacrom; Vividrin

Indications

For the management of patients with bronchial asthma. Also used in the treatment of vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis.

Pharmacology

Cromolyn, a synthetic compound, inhibits antigen-induced bronchospasms and, hence, is used to treat asthma and allergic rhinitis. Cromolyn is used as an ophthalmic solution to treat conjunctivitis and is taken orally to treat systemic mastocytosis and ulcerative colitis.

Mechanism of Action

Cromolyn inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. Cromolyn also may reduce the release of inflammatory leukotrienes. Cromolyn may act by inhibiting calcium influx.

Absorption

1%

Toxicity

cough, nasal congestion, nausea, sneezing and wheezing

Biotrnasformation / Drug Metabolism

Not Available

Contraindications

Intal Inhaler is contraindicated in those patients who have shown hypersensitivity to cromolyn sodium or other ingredients in this preparation.

Drug Interactions

Drug Interaction During Pregnancy: Cromolyn sodium and isoproterenol were studied following subcutaneous injections in pregnant mice. Cromolyn sodium alone in doses up to 540 mg/kg/day (approximately 340 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis) did not cause significant increases in resorptions or major malformations. Isoproterenol alone at a dose of 2.7 mg/kg/day (approximately 7 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis) increased both resorptions and malformations. The addition of 540 mg/kg/day of cromolyn sodium (approximately 340 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis) to 2.7 mg/kg/day of isoproterenol (approximately 7 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis) appears to have increased the incidence of both resorptions and malformations.

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