Brands, Medical Use, Clinical Data
Drug Category
- Anti-Ulcer Agents
- Topical
Dosage Forms
Brands / Synonyms
Collagenase Santyl; Santyl; Santyl (Advance Biofactures Corp)
Description
The enzyme collagenase is derived from fermentation of Clostridium histolyticum
Indications
For treatment of chronic dermal ulcers and severe skin burns
Pharmacology
Used in the treatment of skin ulcers and sever burns, collagenase is able to digest collagen in necrotic tissue at physiological pH. Collagenase thus contributes towards the formation of granulation tissue and subsequent epithelization of dermal ulcers and severely burned areas.
Mechanism of Action
Collagenase is a protease that is specific to collagen. The triple helical region of interstitial collagens is highly resistant to most cell proteinases. However, during remodeling of the connective tissue in such processes as wound healing and metastasis, collagen becomes susceptible to cleavage by collagenases. Collagenase cleaves all 3 alpha helical chains of native Types I, II and III collagens at a single locus by hydrolyzing the peptide bond following the Gly residue of the sequence: Gly 775-(Ile or Leu) 776-(Ala or Leu) 777 located approximately three-fourths of the chain length from each N-terminus
Absorption
Not Available
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
Not Available
Drug Interactions
Not Available
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