Brands, Medical Use, Clinical Data
- Vasoconstrictor Agents
- Local Anesthetics
Brands / Synonyms
Badrock; Bazooka; Benzoylethylecgonine; Benzoylmethylecgonine; Bernice; Bernies; Beta-Cocain; Blast; Blizzard; Blow; Bouncing Powder; Bump; Burese; C" Carrie; Cabello; Candy; Carrie; Caviar; Cecil; Charlie; Chicken Scratch; Cholly; COC; Coca; Cocain; Cocaina; Cocaine Free Base; Cocaine, L-; Cocaine-M; Cocktail; Coke; Cola; Corine; D-pseudococaine; Dama Blanca; Delcaine; Depsococaine; Dextrocaine; Dust; Ecgonine, Methyl Ester, Benzoate; Eritroxilina; Erytroxylin; Flake; Flex; Florida Snow; Foo Foo; Freeze; G-Rock; Girl; Gold Dust; Goofball; Green Gold; Happy Dust; Happy Powder; Happy Trails; Heaven; Hell; Isocaine; Isococain; Isococaine; Jam; Kibbles N' Bits; Kokain; Kokan; Kokayeen; L-Cocain; L-Cocaine; Lady; Leaf; Line; Methyl Benzoylecgonine; Moonrocks; Neurocaine; None; Pimp's Drug; Prime Time; Rock; Sleighride; Snort; Star Dust; Star-Spangled Powder; Sugar; Sweet Stuff; Toke; Toot; Trails; White Girl or Lady; Yeyo; Zip
For the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.
Cocaine is a local anesthetic indicated for the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.
Mechanism of Action
Cocaine produces anesthesia by inhibiting excitation of nerve endings or by blocking conduction in peripheral nerves. This is achieved by reversibly binding to and inactivating sodium channels. Sodium influx through these channels is necessary for the depolarization of nerve cell membranes and subsequent propagation of impulses along the course of the nerve. Cocaine is the only local anesthetic with vasoconstrictive properties. This is a result of its blockade of norepinephrine reuptake in the autonomic nervous system. Cocaine binds differentially to the dopamine, serotonin, and norepinephrine transport proteins and directly prevents the re-uptake of dopamine, serotonin, and norepinephrine into pre-synaptic neurons. Cocaine also produces a number of indirect actions, which alter other neuromodulatory systems (i.e., opioidergic, glutamatergic, and GABAergic systems).
Cocaine is absorbed from all sites of application, including mucous membranes and gastrointestinal mucosa. By oral or intra-nasal route, 60 to 80% of cocaine is absorbed.
Intense agitation, convulsions, hypertension, rhythm disturbance, coronary insufficiency, hyperthermia, rhabdomyolysis, and renal impairment. Oral mouse LD50 = 96 mg/kg
Biotrnasformation / Drug Metabolism
Hepatic. Cocaine is metabolized to benzoylecgonine and ecgonine methyl ester, which are both excreted in the urine. In the presence of alcohol, a further active metabolite, cocaethylene is formed, and is more toxic then cocaine itself.
Cocaine Hydrochloride is contraindicated in patients with a known history of hypersensitivity to the drug or to
the components of the solution.
No information provided.