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Active ingredient: Clofarabine - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C10H11ClFN5O3

Chemical Name

5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol

Chemical Structure

Molecular Weight

303.677 g/mol

Physical State

Solid

Melting Point

Not Available

Water Solubility

Not Available

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Deoxycytidine kinase

Primary Drug Target
NameDNA Polymerase alpha (human)
Gene NamePOLA
SynonymsDNA polymerase alpha catalytic subunit; EC 2.7.7.7
General FunctionReplication, recombination and repair
Specific FunctionPolymerase alpha in a complex with DNA primase is a replicative polymerase
Pathwaymap00230 Purine metabolism map00240 Pyrimidine metabolism map03030 DNA polymerase
Reactiondeoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

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