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Active ingredient: Clofarabine - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name


Chemical Structure

Molecular Weight

303.677 g/mol

Physical State


Melting Point

Not Available

Water Solubility

Not Available

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Deoxycytidine kinase

Primary Drug Target
NameDNA Polymerase alpha (human)
Gene NamePOLA
SynonymsDNA polymerase alpha catalytic subunit; EC
General FunctionReplication, recombination and repair
Specific FunctionPolymerase alpha in a complex with DNA primase is a replicative polymerase
Pathwaymap00230 Purine metabolism map00240 Pyrimidine metabolism map03030 DNA polymerase
Reactiondeoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

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