Brands, Medical Use, Clinical Data
- Antiarrhythmic Agents
- Anticholinergic Agents
Brands / Synonyms
Chlordiazepoxide and Clidinium; Quarzan
For the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.
Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract.
Mechanism of Action
Inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites.
Signs of toxicity include confusion, paralytic ileus, urinary hesitancy/retention, and blurred vision.
Biotrnasformation / Drug Metabolism
Hypersensitivity to anticholinergic agents, narrow-angle glaucoma, GI
obstruction, myasthenia gravis, paralytic ileus, GI atony, toxic megacolon.
Amantadine, tricyclic antidepressants, and MAOIs may increase anticholinergic
effect of clidinium. Clidinium may decrease the effect of phenothiazines, levodopa, and ketoconazole.