Brands, Medical Use, Clinical Data
Drug Category
- Antiarrhythmic Agents
- Anticholinergic Agents
- Antispasmodics
- Parasympatholytics
Dosage Forms
Brands / Synonyms
Chlordiazepoxide and Clidinium; Quarzan
Indications
For the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.
Pharmacology
Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract.
Mechanism of Action
Inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites.
Absorption
Not Available
Toxicity
Signs of toxicity include confusion, paralytic ileus, urinary hesitancy/retention, and blurred vision.
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
Hypersensitivity to anticholinergic agents, narrow-angle glaucoma, GI
obstruction, myasthenia gravis, paralytic ileus, GI atony, toxic megacolon.
Drug Interactions
Amantadine, tricyclic antidepressants, and MAOIs may increase anticholinergic
effect of clidinium. Clidinium may decrease the effect of phenothiazines, levodopa, and ketoconazole.
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