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Active ingredient: Cinacalcet - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C22H22F3N

Chemical Name

N-(1-naphthalen-1-ylethyl)-3-[3-(trifluoromethyl)phenyl]-propan-1-amine

Chemical Structure

Molecular Weight

357.412 g/mol

Physical State

Solid

Melting Point

Not Available

Water Solubility

Slightly soluble (in HCl salt form)

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP3A4; CYP2D6; CYP1A2

Primary Drug Target
NameExtracellular calcium-sensing receptor precursor
Gene NameCASR
SynonymsCaSR; Parathyroid Cell calcium-sensing receptor
Specific FunctionSenses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system

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