Chemisty and Biological Activity
Chemical Formula
C17H14F3N3O2S
Chemical Name
4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
Chemical Structure
Molecular Weight
381.373 g/mol
Physical State
Solid
Melting Point
157-158oC
Water Solubility
Very low water solubility (3.3 mg/L)
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
CYP2C9
Primary Drug Target
| Name | COX-2 | | Gene Name | PTGS2 | | Synonyms | Prostaglandin G/H synthase 2 precursor; EC 1.14.99.1; Cyclooxygenase- 2; COX-2; Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; PHS II | | Specific Function | May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity | | Pathway | map00590 Prostaglandin and leukotriene metabolism | | Reaction | arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O |
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