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Active ingredient: Celecoxib - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name


Chemical Structure

Molecular Weight

381.373 g/mol

Physical State


Melting Point


Water Solubility

Very low water solubility (3.3 mg/L)

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)


Primary Drug Target
Gene NamePTGS2
SynonymsProstaglandin G/H synthase 2 precursor; EC; Cyclooxygenase- 2; COX-2; Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; PHS II
Specific FunctionMay have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity
Pathwaymap00590 Prostaglandin and leukotriene metabolism
Reactionarachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

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