Basic Profile / Key Facts
Drug Category
Dosage Forms
Indications
For the treatment of infections caused by susceptible organisms.
Pharmacology
Ceforanide is a semisynthetic second-generation cephalosporin. The cephalosporins are bactericidal drugs with both gram-positive and gram-negative activity. They inhibit bacterial cell wall synthesis in a way similar to the penicillins.
Mechanism of Action
The bactericidal activity of ceforanide results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
Absorption
Rapidly absorbed following intramuscular injection.
Toxicity
Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions.
Biotrnasformation / Drug Metabolism
The major drug elimination route was urinary excretion with 85% of the dose being excreted unchanged in the urine within 12 hr, and no metabolites with antibiotic activity were observed in urine.
Contraindications
Not Available
Drug Interactions
Not Available
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