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Active ingredient: Cefadroxil - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Anti-bacterial Agents
  • Cephalosporins

Dosage Forms

  • Capsule
  • Tablet
  • Oral liquid

Brands / Synonyms

Baxan; Bidocef; CDX; Cefa-Drops; Cefadroxil; Cefadroxil Micronised Powder; Cefadroxil Monohydrate; Cefamox; Ceforal; Cefradroxil; Cephos; Duracef; Duricef; Kefroxil; Oracefal; Sedral; Sumacef; Ultracef

Indications

For the treatment of the following infections (skin, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staphylococci and Streptococcus pyogenes

Pharmacology

Cefadroxil, a first-generation cephalosporin antibiotic, is used to treat urinary tract infections, skin and skin structure infections, pharyngitis, and tonsillitis.

Mechanism of Action

Like all beta-lactam antibiotics, cefadroxil binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefadroxil interferes with an autolysin inhibitor.

Absorption

Cefadroxil is well absorbed on oral administration; food does not interfere with its absorption.

Toxicity

Nausea, vomiting, diarrhoea, allergic rashes may occur

Biotrnasformation / Drug Metabolism

Not Available

Contraindications

DURICEF (cefadroxil monohydrate, USP) is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.

Drug Interactions

Drug/Laboratory Test Interactions

Positive direct Coombsí tests have been reported during treatment with the cephalosporin antibiotics. In hematologic studies or in transfusion cross-matching procedures when anti-globulin tests are performed on the minor side or in Coombsí testing of newborns whose mothers have received cephalosporin antibiotics before parturition, it should be recognized that a positive Coombsí test may be due to the drug.

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