Brands, Medical Use, Clinical Data
Drug Category
- Anti-bacterial Agents
- Cephalosporins
Dosage Forms
- Capsule
- Tablet
- Oral liquid
Brands / Synonyms
Baxan; Bidocef; CDX; Cefa-Drops; Cefadroxil; Cefadroxil Micronised Powder; Cefadroxil Monohydrate; Cefamox; Ceforal; Cefradroxil; Cephos; Duracef; Duricef; Kefroxil; Oracefal; Sedral; Sumacef; Ultracef
Indications
For the treatment of the following infections (skin, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staphylococci and Streptococcus pyogenes
Pharmacology
Cefadroxil, a first-generation cephalosporin antibiotic, is used to treat urinary tract infections, skin and skin structure infections, pharyngitis, and tonsillitis.
Mechanism of Action
Like all beta-lactam antibiotics, cefadroxil binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefadroxil interferes with an autolysin inhibitor.
Absorption
Cefadroxil is well absorbed on oral administration; food does not interfere with its absorption.
Toxicity
Nausea, vomiting, diarrhoea, allergic rashes may occur
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
DURICEF (cefadroxil monohydrate, USP) is contraindicated in patients with known allergy to the cephalosporin group
of antibiotics.
Drug Interactions
Drug/Laboratory Test Interactions
Positive direct Coombsí tests have been reported during treatment with the cephalosporin antibiotics. In
hematologic studies or in transfusion cross-matching procedures when anti-globulin tests are performed on the minor
side or in Coombsí testing of newborns whose mothers have received cephalosporin antibiotics before
parturition, it should be recognized that a positive Coombsí test may be due to the drug.
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