Brands, Medical Use, Clinical Data
- Antihypocaclemic Agents
- Antiosteporotic Agents
- Nasal spray
- Solution (IM injection)
Brands / Synonyms
Calcitonin 1 precursor; Miacalcin (Novartis)
Synthetic peptide, 32 residues long formulated as a nasal spray
For the treatment of post-menopausal osteoporosis
Calcitonin inhibits bone removal by osteoclasts (bone remodeling cells) and promotes bone formation by osteoblasts. This leads to a net increase in bone mass. Calcitonin also reduces plasma calcium levels and enhances secretion of ions in the kidney.
Mechanism of Action
Calcitonin binds to the calcitonin receptor (found primarily in osteoclasts) which then enhances the production of vitamin D producing enzymes (25-hydroxyvitamine D-24-hydroxylase), leading to greater calcium retention and enhanced bone density. Binding of calcitonin to its receptor also activates adenylyl cyclase and the phosphatidyl-inositol-calcium pathway.
Biotrnasformation / Drug Metabolism