Brands, Medical Use, Clinical Data
Drug Category
- Antihypocaclemic Agents
- Antiosteporotic Agents
Dosage Forms
- Nasal spray
- Solution (IM injection)
Brands / Synonyms
Calcitonin 1 precursor; Miacalcin (Novartis)
Description
Synthetic peptide, 32 residues long formulated as a nasal spray
Indications
For the treatment of post-menopausal osteoporosis
Pharmacology
Calcitonin inhibits bone removal by osteoclasts (bone remodeling cells) and promotes bone formation by osteoblasts. This leads to a net increase in bone mass. Calcitonin also reduces plasma calcium levels and enhances secretion of ions in the kidney.
Mechanism of Action
Calcitonin binds to the calcitonin receptor (found primarily in osteoclasts) which then enhances the production of vitamin D producing enzymes (25-hydroxyvitamine D-24-hydroxylase), leading to greater calcium retention and enhanced bone density. Binding of calcitonin to its receptor also activates adenylyl cyclase and the phosphatidyl-inositol-calcium pathway.
Absorption
Not Available
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
Not Available
Drug Interactions
Not Available
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