Chemisty and Biological Activity
Chemical Formula
C27H44O2
Chemical Name
6-[4-[2-(5-hydroxy-2-methylidene-cyclohexylidene)ethylidene]-7a-methyl- 2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2-methyl-heptan-2-ol
Chemical Structure
Molecular Weight
400.637 g/mol
Physical State
Solid
Melting Point
Not Available
Water Solubility
Insoluble
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
Cytochrome P450 24A1
Primary Drug Target
Name | 25-hydroxyvitamin D-1 alpha hydroxylase | Gene Name | CYP27B1 | Synonyms | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor; EC 1.14.13.13; Calcidiol 1-monooxygenase; 25-OHD-1 alpha- hydroxylase; 25-hydroxyvitamin D(3 1-alpha-hydroxylase; VD3 1A hydroxylase; P450C1 alpha; P450VD1-alpha | General Function | Secondary metabolites biosynthesis, transport and catabolism | Specific Function | Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) plays an important role in normal bone growth, calcium metabolism, and tissue differentiation | Pathway | map00100 Biosynthesis of steroids | Reaction | calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O |
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