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Active ingredient: Calcidiol - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C27H44O2

Chemical Name

6-[4-[2-(5-hydroxy-2-methylidene-cyclohexylidene)ethylidene]-7a-methyl- 2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2-methyl-heptan-2-ol

Chemical Structure

Molecular Weight

400.637 g/mol

Physical State

Solid

Melting Point

Not Available

Water Solubility

Insoluble

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Cytochrome P450 24A1

Primary Drug Target
Name25-hydroxyvitamin D-1 alpha hydroxylase
Gene NameCYP27B1
Synonyms25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor; EC 1.14.13.13; Calcidiol 1-monooxygenase; 25-OHD-1 alpha- hydroxylase; 25-hydroxyvitamin D(3 1-alpha-hydroxylase; VD3 1A hydroxylase; P450C1 alpha; P450VD1-alpha
General FunctionSecondary metabolites biosynthesis, transport and catabolism
Specific FunctionCatalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) plays an important role in normal bone growth, calcium metabolism, and tissue differentiation
Pathwaymap00100 Biosynthesis of steroids
Reactioncalcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O

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