Brands, Medical Use, Clinical Data
Drug Category
- Anti-Wrinkle Agents
- Antidystonic Agents
Dosage Forms
Brands / Synonyms
BoNT/A; Bontoxilysin A; BOTOX (Allegran Inc)
; BOTOX[Contains: Botulinum neurotoxin A light- chain, Botulinum neurotoxin A heavy-chain]; Botulinum neurotoxin type A precursor
Description
Purified botulinum toxin from Clostridium botulinum, purified from culture via dialysis and acid precipitation
Indications
For treatment of cervical dystonia, axillary hyperhidrosis, strabismus, facial wrinkles
Pharmacology
Botox blocks neuromuscular transmission by binding to acceptor sites on motor or sympathetic nerve terminals, entering the nerve terminals, and inhibiting the release of acetylcholine. This inhibition occurs as the neurotoxin cleaves SNAP-25, a protein integral to the successful docking and release of acetylcholine from vesicles situated within nerve endings.
Mechanism of Action
Not Available
Absorption
Not Available
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
Not Available
Drug Interactions
Not Available
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