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Active ingredient: Bleomycin - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C55H84N17O21S3

Chemical Name

3-[[2-[2-[2-[2-[4-[2-[6-amino-2-[1-(2-amino-2-carbamoyl-ethyl)amino-2- carbamoyl-ethyl]-5-methyl-pyrimidin-4-yl]carbonylamino-3-[3-[4- carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-4,5- dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-3-(3H-imidazol-4- yl)propanoyl]amino-3-hydroxy-2-methyl-pentanoyl]amino-3-hydroxy- butanoyl]aminoethyl]-1,3-thiazol-4-yl]-1,3-thiazol-4- yl]carbonylamino]propyl-dimethyl-sulfonium

Chemical Structure

Molecular Weight

1415.56 g/mol

Physical State

Solid

Melting Point

71 oC

Water Solubility

Soluble

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP1A1

Primary Drug Target
NameDNA Ligase III
Gene NameLIG3
SynonymsDNA ligase III; EC 6.5.1.1; Polydeoxyribonucleotide synthase [ATP
General FunctionReplication, recombination and repair
Specific FunctionInteracts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents
ReactionATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m

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