Chemisty and Biological Activity
Chemical Formula
C55H84N17O21S3
Chemical Name
3-[[2-[2-[2-[2-[4-[2-[6-amino-2-[1-(2-amino-2-carbamoyl-ethyl)amino-2- carbamoyl-ethyl]-5-methyl-pyrimidin-4-yl]carbonylamino-3-[3-[4- carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-4,5- dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-3-(3H-imidazol-4- yl)propanoyl]amino-3-hydroxy-2-methyl-pentanoyl]amino-3-hydroxy- butanoyl]aminoethyl]-1,3-thiazol-4-yl]-1,3-thiazol-4- yl]carbonylamino]propyl-dimethyl-sulfonium
Chemical Structure
Molecular Weight
1415.56 g/mol
Physical State
Solid
Melting Point
71 oC
Water Solubility
Soluble
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
CYP1A1
Primary Drug Target
Name | DNA Ligase III | Gene Name | LIG3 | Synonyms | DNA ligase III; EC 6.5.1.1; Polydeoxyribonucleotide synthase [ATP | General Function | Replication, recombination and repair | Specific Function | Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents | Reaction | ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m |
|