Brands, Medical Use, Clinical Data
Drug Category
- Anticoagulants
- Antithrombotic Agents
Dosage Forms
- Solution (IV Injection and Infusion)
Brands / Synonyms
Angiomax; Angiomax (Medicines Co or MDCO)
Description
Synthetic 20 residue peptide (thrombin inhibitor)
Indications
For treatment of heparin-induced thrombocytopenia
Pharmacology
Angiomax directly inhibits thrombin by specifically binding both to the catalytic site and to the anion-binding exosite of circulating and clot-bound thrombin. Thrombin is a serine proteinase that plays a central role in the thrombotic process, acting to cleave fibrinogen into fibrin monomers and to activate Factor XIII to Factor XIIIa, allowing fibrin to develop a covalently cross-linked framework which stabilizes the thrombus; thrombin also activates Factors V and VIII, promoting further thrombin generation, and activates platelets, stimulating aggregation and granule release
Mechanism of Action
Inhibits the action of thrombin by binding both to its catalytic site and to its anion-binding exosite.
Absorption
Not Available
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
Not Available
Drug Interactions
Not Available
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