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Active ingredient: Benzphetamine - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C17H21N

Chemical Name

N-benzyl-N-methyl-1-phenyl-propan-2-amine

Chemical Structure

Molecular Weight

239.355 g/mol

Physical State

Solid

Melting Point

152-153 oC

Water Solubility

Readily soluble

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP2C8

Primary Drug Target
NameAlpha-2A adrenergic receptor
Gene NameADRA2A
SynonymsAlpha-2A adrenoceptor; Alpha-2A adrenoreceptor; Alpha-2AAR subtype C10
Specific FunctionAlpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol

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