Brands, Medical Use, Clinical Data
- Capsule (soft gelatin, 100 mg)
Brands / Synonyms
Benzonatate [Usan:Ban:Inn]; Benzonatato [Inn-Spanish]; Benzonatatum [Inn-Latin]; Benzononantin; Benzononatine; Exangit; Tesalon; Tessalin; Tessalon; Tessalon Perles; Tessalon-Ciba; Ventussin; Ventussin-Loz
For the symptomatic relief of cough
Benzonatate, a non-narcotic antitussive agent chemically related to tetracaine and other ester-type local anesthetics, is used to suppress cough associated with both acute and chronic respiratory conditions.
Mechanism of Action
Benzonatate acts peripherally, anesthetizing the stretch receptors of vagal afferent fibers in the alveoli of the lungs, bronchi, and pleura. When applied locally, Benzonatate binds within the intracellular portion of voltage-gated sodium channels, decreasing the rate of membrane depolarization and increasing the threshold for electrical excitability.
Restlessness, tremors, seizures and unconsciousness.
Biotrnasformation / Drug Metabolism
Benzonatate is hydrolyzed to para-aminobenzoic acid (PABA) by plasma esterases
Hypersensitivity to benzonatate or related compounds.
No information provided.