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Active ingredient: Benzonatate - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Antitussives

Dosage Forms

  • Capsule (soft gelatin, 100 mg)

Brands / Synonyms

Benzonatate [Usan:Ban:Inn]; Benzonatato [Inn-Spanish]; Benzonatatum [Inn-Latin]; Benzononantin; Benzononatine; Exangit; Tesalon; Tessalin; Tessalon; Tessalon Perles; Tessalon-Ciba; Ventussin; Ventussin-Loz

Indications

For the symptomatic relief of cough

Pharmacology

Benzonatate, a non-narcotic antitussive agent chemically related to tetracaine and other ester-type local anesthetics, is used to suppress cough associated with both acute and chronic respiratory conditions.

Mechanism of Action

Benzonatate acts peripherally, anesthetizing the stretch receptors of vagal afferent fibers in the alveoli of the lungs, bronchi, and pleura. When applied locally, Benzonatate binds within the intracellular portion of voltage-gated sodium channels, decreasing the rate of membrane depolarization and increasing the threshold for electrical excitability.

Absorption

Not Available

Toxicity

Restlessness, tremors, seizures and unconsciousness.

Biotrnasformation / Drug Metabolism

Benzonatate is hydrolyzed to para-aminobenzoic acid (PABA) by plasma esterases

Contraindications

Hypersensitivity to benzonatate or related compounds.


Drug Interactions

No information provided.

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