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Active ingredient: Benzonatate - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Antitussives

Dosage Forms

  • Capsule (soft gelatin, 100 mg)

Brands / Synonyms

Benzonatate [Usan:Ban:Inn]; Benzonatato [Inn-Spanish]; Benzonatatum [Inn-Latin]; Benzononantin; Benzononatine; Exangit; Tesalon; Tessalin; Tessalon; Tessalon Perles; Tessalon-Ciba; Ventussin; Ventussin-Loz


For the symptomatic relief of cough


Benzonatate, a non-narcotic antitussive agent chemically related to tetracaine and other ester-type local anesthetics, is used to suppress cough associated with both acute and chronic respiratory conditions.

Mechanism of Action

Benzonatate acts peripherally, anesthetizing the stretch receptors of vagal afferent fibers in the alveoli of the lungs, bronchi, and pleura. When applied locally, Benzonatate binds within the intracellular portion of voltage-gated sodium channels, decreasing the rate of membrane depolarization and increasing the threshold for electrical excitability.


Not Available


Restlessness, tremors, seizures and unconsciousness.

Biotrnasformation / Drug Metabolism

Benzonatate is hydrolyzed to para-aminobenzoic acid (PABA) by plasma esterases


Hypersensitivity to benzonatate or related compounds.

Drug Interactions

No information provided.

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