Brands, Medical Use, Clinical Data
- Local Anesthetics
- Dental paste
- Film-forming gel
Brands / Synonyms
Aethoform; Amben Ethyl Ester; Americaine; Anaesthan-Syngala; Anaesthesin; Anaesthin; Anestezin; Anesthesin; Anesthesine; Anesthone; Baby Anbesol; Chlorphenylcaine; Dermoplast; Ethoform; Ethyl Aminobenzoate; Ethyl P-Aminobenzoate; Ethyl P-Aminophenylcarboxylate; Ethylester Kyseliny P-Aminobenzoove; Hurricaine; Identhesin; Keloform; Norcain; Norcaine; Ora-Jel; Orthesin; P-Aminobenzoic Acid, Ethyl Ester; P-Carbethoxyaniline; P-Ethoxycarboxylic Aniline; Parathesin; Parathesine; Solarcaine; Solu H; Topcaine
For general use as a lubricant and topical anesthetic on esophagus, larynx, mouth, nasal cavity, rectum, respiratory tract or trachea, urinary tract, vagina. It is also used to suppress gag reflex.
Benzocaine is a local anesthetic commonly used as a topical pain reliever. It is the active ingredient in many over-the-counter analgesic ointments. It is also indicated for general use as a lubricant and topical anesthetic on intratracheal catheters and pharyngeal and nasal airways to obtund the pharyngeal and tracheal reflexes; on nasogastric and endoscopic tubes; urinary catheters; laryngoscopes; proctoscopes; sigmoidoscopes and vaginal specula.
Mechanism of Action
Benzocaine binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.
LD50=3040 mg/kg (rat, oral)
Biotrnasformation / Drug Metabolism
Known allergy or hypersensitivity to benzocaine.
No information is available.