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Active ingredient: Benzocaine - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Anesthetics
  • Antipruritics
  • Local Anesthetics

Dosage Forms

  • Dental paste
  • Film-forming gel
  • Liquid
  • Ointment

Brands / Synonyms

Aethoform; Amben Ethyl Ester; Americaine; Anaesthan-Syngala; Anaesthesin; Anaesthin; Anestezin; Anesthesin; Anesthesine; Anesthone; Baby Anbesol; Chlorphenylcaine; Dermoplast; Ethoform; Ethyl Aminobenzoate; Ethyl P-Aminobenzoate; Ethyl P-Aminophenylcarboxylate; Ethylester Kyseliny P-Aminobenzoove; Hurricaine; Identhesin; Keloform; Norcain; Norcaine; Ora-Jel; Orthesin; P-Aminobenzoic Acid, Ethyl Ester; P-Carbethoxyaniline; P-Ethoxycarboxylic Aniline; Parathesin; Parathesine; Solarcaine; Solu H; Topcaine

Indications

For general use as a lubricant and topical anesthetic on esophagus, larynx, mouth, nasal cavity, rectum, respiratory tract or trachea, urinary tract, vagina. It is also used to suppress gag reflex.

Pharmacology

Benzocaine is a local anesthetic commonly used as a topical pain reliever. It is the active ingredient in many over-the-counter analgesic ointments. It is also indicated for general use as a lubricant and topical anesthetic on intratracheal catheters and pharyngeal and nasal airways to obtund the pharyngeal and tracheal reflexes; on nasogastric and endoscopic tubes; urinary catheters; laryngoscopes; proctoscopes; sigmoidoscopes and vaginal specula.

Mechanism of Action

Benzocaine binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.

Absorption

Not Available

Toxicity

LD50=3040 mg/kg (rat, oral)

Biotrnasformation / Drug Metabolism

Not Available

Contraindications

Known allergy or hypersensitivity to benzocaine.

Drug Interactions

No information is available.

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