Brands, Medical Use, Clinical Data
Drug Category
- Diuretics, Thiazide
- Antihypertensive Agents
Dosage Forms
Brands / Synonyms
Aprinox; Bendrofluazide; Bendroflumethazide; Bendroflumethiazide [Inn]; Bendroflumethiazidum [Inn-Latin]; Bendroflumetiazida [Inn-Spanish]; Bendroflumetiazide [Dcit]; Bendrofumethiazide; Bentride; Benuron; Benzhydroflumethiazide; Benzy-Rodiuran; Benzydroflumethiazide; Benzylhydroflumethiazide; Benzylrodiuran; Berkozide; BHFT; Bristuric; Bristuron; Centyl; Corgard; Corzide; Flumersil; Flumesil; FT 8; Intolex; Livesan; Naigaril; Nateretin; Naturetin; Naturetin-2.5; Naturine; Neo-Naclex; Neo-Rontyl; Niagaril; Nikion; Orsile; Pluryl; Pluryle; Plusuril; Poliuron; Rautrax N; Rauzide; Relan Beta; Repicin; Salural; Salures; Sinesalin; Sodiuretic; Thiazidico; Urlea
Indications
For the treatment of high blood pressure and management of edema
Pharmacology
Bendroflumethiazide, a thiazide diuretic, removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Mechanism of Action
As a diuretic, bendroflumethiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like bendroflumethiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of bendroflumethiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
Absorption
Absorbed relatively rapidly after oral administration
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
Contraindicated in the following: diabetes mellitus (thiazide
diuretics may increase the amount of sugar in the blood), gout (history of), lupus erythematosus (history of),
pancreatitis (thiazide diuretics may make these conditions worse), heart or blood vessel disease (thiazide diuretics
may cause high cholesterol levels or high triglyceride levels), liver disease, and kidney disease (higher blood
levels of the thiazide diuretic may occur, which may prevent the thiazide diuretic from working properly).
Drug Interactions
May interact with the following: cholestyramine, colestipol (use with
thiazide diuretics may prevent the diuretic from working properly; take the diuretic at least 1 hour before or 4
hours after cholestyramine or colestipol), digitalis glycosides (use with thiazide diuretics may cause high blood
levels of digoxin, which may increase the chance of side effects), and lithium (use with thiazide diuretics may cause
high blood levels of lithium, which may increase the chance of side effects).
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