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Active ingredient: Bacitracin - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C66H103N17O16S

Chemical Name

4-[2-[[2-(1-amino-2-methyl-butyl)-4,5-dihydro-1,3-thiazol-5- yl]carbonylamino]-4-methyl-pentanoyl]amino-5-[1-[[18-(3-aminopropyl)-12- benzyl-15-butan-2-yl-3-(carbamoylmethyl)-6-(carboxymethyl)-9-(3H-imidazol- 4-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19- heptazacyclopentacos-21-yl]carbamoyl]-2-methyl-butyl]amino-5-oxo- pentanoic acid

Chemical Structure

Molecular Weight

1422.69 g/mol

Physical State

Solid

Melting Point

221 - 225 oC

Water Solubility

Freely soluble

Isoelectric Point

Not Available

Organisms Affected

Enteric bacteria and other eubacteria

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameProbable low molecular weight protein-tyrosine-phosphatase epsP
Gene NameepsP
SynonymsEC 3.1.3.48
General FunctionSignal transduction mechanisms
Specific FunctionMay be involved in assembly or function of the EPS I polymerization/export complex and/or the epsB ATPase. Alternatively it may function in the removal of the terminal phosphate from C55-isoprenyl pyrophosphate in order to recycle the C55-isoprenyl phosphate lipid carrier used in the synthesis of polysaccharide repeat units
Reactionprotein tyrosine phosphate + H2O = protein tyrosine + phosphate

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