Chemisty and Biological Activity
Chemical Formula
C22H24ClN3O
Chemical Name
4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one
Chemical Structure
Molecular Weight
381.898 g/mol
Physical State
Solid
Melting Point
225 oC (hydrochloride salt)
Water Solubility
Sparingly soluble (hydrochloride salt)
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
Not Available
Primary Drug Target
| Name | Histamine H1 Receptor | | Gene Name | HRH1 | | Synonyms | Histamine H1 receptor | | Specific Function | In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system |
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