Active ingredient: Azelaic Acid - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C9H16O4

Chemical Name

nonanedioic acid

Chemical Structure

Molecular Weight

188.221 g/mol

Physical State

Solid

Melting Point

106.5 oC

Water Solubility

2400 mg/L (20°C)

Isoelectric Point

4.55

Organisms Affected

Various aerobic and anaerobic microorganisms

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target

Name	3-oxo-5-alpha-steroid 4-dehydrogenase 2
Gene Name	SRD5A2
Synonyms	EC 1.3.99.5; Steroid 5- alpha-reductase 2; SR type 2; 5 alpha-SR2
Specific Function	Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology
Pathway	map00120 Bile acid biosynthesis map00150 Androgen and estrogen metabolism
Reaction	a 3-oxo-5alpha-steroid + acceptor = a 3-oxo-delta4-steroid + reduced acceptor