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Active ingredient: Atorvastatin - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C33H35FN2O5

Chemical Name

7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-yl-pyrrol-1- y l]-3,5-dihydroxy-heptanoic acid

Chemical Structure

Molecular Weight

558.64 g/mol

Physical State

Solid

Melting Point

159.2-160.7oC

Water Solubility

Sodium salt soluble in water, 20.4 ug/mL (pH 2.1), 1.23 mg/mL (pH 6.0)

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP3A4

Primary Drug Target
NameHMG-CoA Reductase
Gene NameHMGCR
Synonyms3-hydroxy-3-methylglutaryl-coenzyme A reductase; EC 1.1.1.34; HMG-CoA reductase
General FunctionLipid transport and metabolism
Specific FunctionThis transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis
Pathwaymap00100 Biosynthesis of steroids
Reaction(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+

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