Chemisty and Biological Activity
Chemical Formula
C28H31FN4O
Chemical Name
1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidyl]- benzoimidazol-2-amine
Chemical Structure
Molecular Weight
458.571 g/mol
Physical State
Solid
Melting Point
149.1oC
Water Solubility
432 mg/L
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
CYP3A4
Primary Drug Target
Name | Histamine H1 Receptor | Gene Name | HRH1 | Synonyms | Histamine H1 receptor | Specific Function | In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system |
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