Active ingredient: Aspirin - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C9H8O4

Chemical Name

2-acetyloxybenzoic acid

Chemical Structure

Molecular Weight

180.157 g/mol

Physical State

Solid

Melting Point

135 oC (boiling point 140 oC)

Water Solubility

4.6 mg/mL

Isoelectric Point

3.49

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target

Name	Prostaglandin G/H synthase 1 [Precursor]
Gene Name	PTGS1
Synonyms	EC 1.14.99.1; Cyclooxygenase-1; COX-1; Prostaglandin-endoperoxide synthase 1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1
Specific Function	May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells
Pathway	map00590 Prostaglandin and leukotriene metabolism
Reaction	arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O