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Active ingredient: Asparaginase - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Antineoplastic Agents

Dosage Forms

  • Powder for solution
  • Solution (IV or IM injection)

Brands / Synonyms

Elspar; Elspar (Merck & Co. Inc) ; L-asparagine amidohydrolase; Putative L-asparaginase precursor

Description

L-asparagine amidohydrolase from E. coli

Indications

For treatment of acute lympocytic leukemia and non-Hodgkins lymphoma

Pharmacology

In a significant number of patients with acute leukemia, the malignant cells are dependent on an exogenous source of asparagine for survival. Normal cells, however, are able to synthesize asparagine and thus are affected less by the rapid depletion produced by treatment with the enzyme asparaginase. Elspar exploits a metabolic defect in asparagine synthesis of some malignant cells.

Mechanism of Action

Asparaginase converts asparagine to aspartic acid and ammonia. It facilitates production of oxaloacetate which is needed for general cellular metabolism. Some malignant cells lose the ability to produce asparagine and so the loss of exogenous sources of asparagine leads to cell death.

Absorption

Not Available

Toxicity

Not Available

Biotrnasformation / Drug Metabolism

Not Available

Contraindications

Not Available

Drug Interactions

Not Available

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