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Active ingredient: Argatroban - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C23H36N6O5S

Chemical Name

1-[5-guanidino-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8- yl)sulfonylamino]pentanoyl]-4-methyl-piperidine-2-carboxylic acid

Chemical Structure

Molecular Weight

508.635 g/mol

Physical State

Solid

Melting Point

Not Available

Water Solubility

Not Available

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameProthrombin
Gene NameF2
SynonymsProthrombin precursor; EC 3.4.21.5; Coagulation factor II
Specific FunctionThrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C
ReactionSelective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B

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