Brands, Medical Use, Clinical Data
- Diagnostic Agents
- Imaging Agents
Brands / Synonyms
CEA-Scan; CEA-Scan (Immunomedics Inc)
Reduced Fab fragment of the murine IgG1 monoclonal antibody IMMU-4 (also called NP-4) with specificity for carcinoembryonic antigen (CEA) covalently labeled with Technitium 99. The molecule has a molecular weight of ~54,000 Daltons.
For imaging colorectal tumors
Binds to the carcinoembryonic antigen, which is a cell surface protein generally overexpressed in colon (and other) cancers. The radioactive Tc99, which is covalently attached to the antibody, allows radiodiagnostic detection of CEA expressing cells and tumors
Mechanism of Action
Binds selectively to cell-surface carcinoembryonic antigen (CEA) expressed on colorectal tumors.
Biotrnasformation / Drug Metabolism
Most likely removed by opsonization via the reticuloendothelial system, or by human antimurine antibody production