Chemisty and Biological Activity
Chemical Formula
C23H21F7N4O3
Chemical Name
5-[[2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)- morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one
Chemical Structure
Molecular Weight
534.427 g/mol
Physical State
Solid
Melting Point
Not Available
Water Solubility
Practically insoluble
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
CYP3A4
Primary Drug Target
| Name | P/neurokinin 1 Receptor | | Gene Name | TACR1 | | Synonyms | Substance-P receptor; SPR; NK-1 receptor; NK-1R; Tachykinin receptor 1 | | Specific Function | This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin K. |
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